IGFBP-6 RNA is highly expressed in eosinophils [10,30] and IGFBP-6 gene has been linked to allergic asthma [31,32,33] the latter suggesting it may play a role in Th2 response, favoring an imbalance of the immune response towards immunosuppressive stimuli. This evidence concerns the gene IGFBP6 and allergic asthma.