It is well known that IGFBP-6 mRNA and protein expression levels are high in the kidney and, of interest, they are abundant in plasma of adults and children with Chronic Kidney Disease (CKD) or End Stage Renal Disease (ERSD) [51,52], suggesting that IGFBP-6 might be related to the kidney development process. This evidence concerns the gene IGFBP6 and stage 5 chronic kidney disease.