EGFL6 and obesity due to melanocortin 4 receptor deficiency: Apart from this, EGFL6 has been identified as an AT-secreted protein in adult humans, where it has been implicated in the regulation of adipose progenitor cell proliferation and obesity-related AT expansion, while a link to obesity-related adipocyte hypertrophy, AT dysfunction, and metabolic impairment was proposed but not analysed in this study [20].