LEP and Other metabolic disease: In line with this, we observed significantly positive associations of adipocyte EGFL6 expression with BMI SDS of children as well as with parameters indicative for early AT dysfunction, such as adipocyte size, macrophage infiltration into AT, serum hs-CRP and leptin levels, and metabolic disease (i.e., HOMA-IR), which was independent of the age and sex of the children (Figure 3C).