LEP and obesity due to melanocortin 4 receptor deficiency: We observed a significant downregulation of EGFL6 expression in subcutaneous AT with increasing weight loss underlining its association with obesity state (Figure 3D), while there was no significant association with hs-CRP (R = 0.085, p = 0.587), leptin (R = 0.326, p = 0.120), or HOMA-IR (R = 0.085, p = 0.587) change.