The pancreas responds to insulin resistance and resultant high blood glucose by hypersecreting insulin, an anabolic endogenous hormone, which can elicit changes in insulin-like growth factor-1 receptor crosstalk [33], organomegaly [34], hepatic growth hormone receptor activity [35], TNF-α production by adipose tissue [36], insulin-induced-insulin-resistance [37], and adrenocortical tumors (Figure 2) [5]. Here, INS is linked to Insulin resistance.