Hepatic fibrosis was demonstrated by increased mRNA levels of α-SMA and Col6α3 pro-fibrogenic genes (Figure 7C) and manifested by increased interstitial chicken-wire bridging pattern of collagen deposition in Sirius Red-stained Ldlr−/−VECadCre+Cc1flfl liver sections (Figure 7B panel d vs. a–c). This evidence concerns the gene COL6A3 and Hepatic fibrosis.