The current studies revealed that feeding the insulin sensitive Ldlr−/−VECadCre+Cc1fl/fl mice with a high cholesterol diet for 3–5 months caused hypercholesterolemia (mostly LDL-C) without insulin resistance, visceral obesity or increase in plasma NEFA and other dyslipidemia-related changes. This evidence concerns the gene INS and familial hypercholesterolemia.