These data are in agreement with a previous study, which found that 2-deoxyglucose (2DG), an analog of glucose that blocks glycolysis, reduced cyst progression in (Cy/+) Han:SPRD rats through the increased phosphorylation of AMPK-α and restoration of ERK signaling in the absence of a reduction in mTOR/S6K [32]. This evidence concerns the gene RPS6KB1 and cyst.