To explore the anti-tumorigenic effects of AC-265347, we evaluated tumor growth inhibition induced by calcimimetics in three different mouse models, carrying LA-N-1 cells, HSJD-NB-001 or HSJD-NB-004 patient-derived xenografts (PDX) models, with different basal expression levels of CaSR, evaluated in early-passage tissues (p2) (Supplementary Figure S1A). The gene discussed is CASR; the disease is neoplasm.