Increased expression of the antimicrobial peptide genes Defb4, S100a8, and S100a9, as well as the keratinocyte proliferation marker Krt16, was observed in the IMQ-treated groups (Figure 3), which were not augmented by HFD feeding or Apoe deficiency. This evidence concerns the gene APOE and hyperinsulinemic hypoglycemia, familial, 4.