APOE and Abnormality of the skin: Exacerbated inflammatory skin changes in the HFD-fed Apoe−/− mice were confirmed by the increased expression of IL-23p19, signal transducer and activator of transcription-3 (STAT3), and phospho-STAT3 in the epidermis of inflamed skin (Figure S1), which are known to be activated in psoriatic skin [19,20].