These mechanisms are linked to neurotransmitters involved in the excitatory–inhibitory balance (glutamate, GABA, acetylcholine, and noradrenaline), alterations in ion channels (sodium, potassium, and calcium channels), changes in neuronal networks, anatomopathological hallmarks of AD (amyloid and tau), neuroinflammation, and genetic risk factors. Here, MAPT is linked to Alzheimer disease.