In studies using ex-labeled VLDL1 and VLDL2 particles to investigate VLDL kinetics during hyperinsulinemia, the size (TG/Apo B ratio) and Apo B-100 concentration were significantly reduced in healthy men but were unaltered in men with type 2 diabetes due to hyperinsulinemia, suggesting that the fatty acid oxidation rate was substantially suppressed in diabetic subjects [89,96]. The gene discussed is APOB; the disease is hyperinsulinism.