In line with previous reports [41], indicating an important IgE cross-reactivity among Lep d 2, Gly d 2 and Tyr p 2, and a partial cross-reactivity between T. putrescentiae and G. domesticus/L. destructor, we found that more than 50% of the individuals were all concomitantly sensitized to these three molecules, regardless of the asthma severity. This evidence concerns the gene IGHE and asthma.