The current study showed several restrictions, as 14 subjects (10.52%) with a positive sIgE response to the raw extract of SM (with 3 and 2 out of those 14 patients showing a positive SPT to G. domesticus and A. siro, respectively) could not be identified through the proposed molecular panel, and also, a limited number of patients was studied, making these findings challenging to match with other SM-sensitive asthma cohorts, exposed to different mite populations. Here, AGXT is linked to asthma.