A marked IgE-binding intensity was found around 13, 14, 17, 30, 35, 50 and 55 kDa for B. tropicalis in the majority of subjects, and around 14–16 kDa for patients with moderate asthma with a more complex repertoire, including 14–16, 25, 40 and 50 kDa for L. destructor in those with the severe asthma presentation. The gene discussed is IGHE; the disease is asthma.