Since the metabolic alteration by shifting fatty acids to glucose is linked to studies of patients and mouse models of diabetes or ischemic cardiomyopathy showing an increase in the expression of cardiac KLF5 [132,133,134,135], the relation between KLF5 and metabolic alteration in glycolysis in the heart should be considered. The gene discussed is KLF5; the disease is ischemic cardiomyopathy.