Furthermore, a comprehensive analysis of WES and RNA-seq transcriptome analysis revealed that the PIK3CG c.2480C > G variant was correlated with gene overexpression in the corresponding cell line, whereas PIK3CA c.1143C > G was associated with a corresponding decrease in gene expression in tumor cell lines, but at a level still higher than non-neoplastic controls (Figure 3b). This evidence concerns the gene PIK3CA and neoplasm.