The patients with either high resistin levels/low RETN WGRS or high sST2 levels/low IL1RL1 WGRS and the patients with both high resistin levels/low RETN WGRS and high sST2 levels/low IL1RL1 WGRS had significantly higher rates of all-cause mortality and MACEs after adjustment for baseline characteristics and diseases such as hypertension, diabetes mellitus, or hyperlipidemia. The gene discussed is RETN; the disease is Hypertension.