Given the reported relation of human adenosine A2a receptor’s deleterious mutation and rare childhood-onset, infection-associated acute encephalopathies with epileptic seizures [69] (https://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=22322, accessed on 20 March 2022), it would also be important to further extend the analysis of the presented interaction between the orthologous mouse adenosine A2a receptor and Gpr37 proteins in the hippocampus and striatum [23,24,25,26,27], as well as investigate the possible effects of Gpr37’s modulation on susceptibility to seizures [40]. The gene discussed is ADORA2A; the disease is Acute encephalopathy.