The immunohistochemical analysis of monocyte-/macrophage-derived cells (F4/80+ cells) showed that macrophage infiltration of pancreatic acini increased in T2D (p < 0.05) and decreased in APH-treated diabetic rats (p < 0.05) (Figure 3a1–a3). The gene discussed is APEH; the disease is type 2 diabetes mellitus.