For this purpose, we use different TLR ligands towards cell surface receptors—bacterial lipopolysaccharide (LPS) for TLR4; imidazoquiline amine analog to guanosine (Imiquimod) for TLR7; synthetic bacterial triacylated lipoprotein for TLR2/TLR1)—and endosomal membrane receptor (poly I:C for TLR3), in order to simulate bacterial (cell wall bacterial components) or viral infections (dsRNA and ssRNA) [34,35]. The gene discussed is TLR4; the disease is viral infectious disease.