In addition, miR-222-3p and miR-409-3p share four experimentally validated target genes, namely the serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A); vestigial-like family member 4 (VGLL4); reversion-inducing cysteine rich protein with kazal motifs (RECK); and O-6-methylguanine-DNA methyltransferase (MGMT) and, with the exception of VGLL4, low levels of all these genes have been related with T2D, as reported in Table 4. Here, RECK is linked to type 2 diabetes mellitus.