MGMT and type 2 diabetes mellitus: In addition, miR-222-3p and miR-409-3p share four experimentally validated target genes, namely the serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A); vestigial-like family member 4 (VGLL4); reversion-inducing cysteine rich protein with kazal motifs (RECK); and O-6-methylguanine-DNA methyltransferase (MGMT) and, with the exception of VGLL4, low levels of all these genes have been related with T2D, as reported in Table 4.