Most CNVs found were inherited from either parent with a normal phenotype; only one patient identified two de novo microduplications at 19q13.42, which included the NLRP (Nucleotide-binding oligomerization domain, Leucine-rich Repeat and Pyrin domain) containing family (NLRP2, NLRP9 and NLRP11), as well as IL-11 and HSPBP1 gene (Hsp70-binding protein 1), all of which play a major role in inflammatory pathways and sJIA pathogenesis. Here, HSPBP1 is linked to systemic-onset juvenile idiopathic arthritis.