It has been shown that pharmacological activation of PPARα receptors by their agonists gemfibrozil and 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid (Wy14643) induces autophagy in HM microglial and U251 human glioma cells expressing a mutant form of human APP (APP-p.M671L). Here, APP is linked to central nervous system cancer.