Genomic and epigenomic analysis of 1.2 million CpG and CpH sites in enhancers of prefrontal cortex neurons in 101 people with no, mild, moderate, and severe AD showed that hypomethylation of enhancers in the DSCAML1 gene (the protein encoded by this gene is a member of the Ig superfamily of cell-adhesion molecules and is involved in neuronal differentiation in AD is associated with the activation of BACE1 transcripts and an increase in the number of amyloid plaques, neurofibrillary tangles, and the development of cognitive impairment [124]. The gene discussed is DSCAML1; the disease is Alzheimer disease.