Furthermore, intracameral inoculation of AAV-2/9 containing a CMV-driven MMP-3 gene into wild-type (C57BL/6) mice elevated the aqueous concentration and activity of MMP-3 secreted from the corneal endothelium; interestingly, this elevated MMP-3 expression enhanced outflow facility and reduced IOP, suggesting that MMP-3 plays a significant role in mitigating glaucoma [178]. Here, MMP3 is linked to glaucoma.