The treatment also prevented the dexamethasone-stimulated synthesis of ECM components and endoplasmic reticulum stress markers in primary human trabecular meshwork cells and upregulated the gene expression and activity of MMP-9 in the same model, indicating that sodium 4-phenylbutyrate was able to degrade abnormal extracellular matrix accumulation in glaucoma [216]. The gene discussed is MMP9; the disease is glaucoma.