SROs with candidate genes were found in the established risk loci for other syndromes known to be associated with hypospadias, such as Silver–Russell Syndrome (PSMD13); 13q Deletion Syndrome (COL4A1); and 22q Deletion/Duplication Syndromes, which includes DiGeorge Syndrome (CRKL). The gene discussed is CRKL; the disease is hypospadias.