GJB6 and Abnormality of the skin: Although a variety of in vitro functional studies of Cx26, Cx30, and Cx43 mutations have been carried out and various possible pathogenic changes (described in the Section 3 of this review) have been revealed, it remains unclear why some Cx26 and Cx30 mutations cause deafness without skin diseases in vivo but others induce syndromic deafness accompanied with skin changes.