In addition, macrophage-related cochlear cell damage in Cx26 knockout mice and macrophage-mediated demyelination of peripheral nerves in Cx32 null mice indicate that secondary inflammation involving macrophages may be involved in the pathogenic processes of different hereditary diseases, which provides new insight regarding the pathogenesis of congenital cataract, congenital heart diseases, and hereditary skin diseases. Here, GJB2 is linked to congenital heart disease.