TGFB1 and renal fibrosis: It is speculated that sulfatides contribute to disease progression by mediating the reabsorption of profibrotic chemokines and the stress-induced secretion of cytokines in Alport podocytes, thereby affecting monocyte infiltration into the renal interstitium and triggering the production of TGF-β1, which plays an important role in the pathogenesis of renal fibrosis [81].