Treatment of rat and mouse models of DKD with a non-selective S1PR agonist FTY720 or a S1PR1 agonist SEW2871 was shown to reduce proteinuria [56], while inhibition of S1PR2 by berberine prevented renal injury in diabetic rats [126], suggesting that targeting S1P receptors or S1P signaling can lead to the development of therapeutics to treat glomerular diseases. The gene discussed is S1PR1; the disease is diabetic kidney disease.