In support of a role for S1PR signaling in kidney diseases, inhibition of S1PR2 prevented renal injury in mouse models of DKD [56], while S1PR1 activation using agonists such as SEW2871 and FTY720 prevented STZ-induced renal damage in diabetic mice by restoring the protein expression of nephrin and podocin [56]. The gene discussed is S1PR1; the disease is diabetic kidney disease.