At the molecular levels, this coincided with the downregulation of Nfkb1, Snai1 and Stat3 mRNA, in line with our previous study showing that PA and Cer were powerful inhibitors of an IL-10-STAT3-NF-κB signaling axis regulating EMT in colorectal cancer [44]. The gene discussed is NFKB1; the disease is colorectal cancer.