While several aspects of IMQ-induced dermatitis have been analyzed (including skin thickness, blood perfusion, semiquantitative histopathological evaluation, determination of scaling score to monitor psoriatic symptoms, and collection of spleen and body weight), little data are available on changes in psoriatic skin permeability, and it has not been previously investigated in TRPV1 and TRPA1 knockout mice. Here, TRPA1 is linked to skin disorder.