In addition, prospective analysis of propranolol administered in an off-label use on ccRCC-VHL tumor growth kinetics in VHL patients showed a stabilization of RCCs size during propranolol treatment (from 15 to 47 months), as it has also been observed in the head and neck, esophageal, stomach, colon, and prostate cancers [54]. The gene discussed is VHL; the disease is von Hippel-Lindau disease.