First, recent studies indicate that EGFR in glioblastoma occurs in several forms, including EGFRvIII, EGFR with kinase domain duplication (EGFR-KDD), EGFR fused with SEPT14 (EGFR-SEPT14), and EGFR with point mutations in both intracellular and extracellular domains [6,11,12,13]. The gene discussed is EGFR; the disease is glioblastoma.