A recent study found that CAFs could induce EMT in cell lines of EGFR-mutated NSCLC resistant to EGFR TKI gefitinib, particularly when there was an increment in the expression of Annexin A2, whose knockdown was found to completely reverse EMT phenotype and gefitinib resistance induced by CAFs [186]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.