Adipose-derived autotaxin is upregulated in obesity in both mice and humans [18], while circulating autotaxin levels are a biomarker of fibrosis in non-alcoholic fatty liver disease (NAFLD) [19], and high levels of autotaxin and LPA are found in many different tumor types [20]. The gene discussed is ENPP2; the disease is obesity due to melanocortin 4 receptor deficiency.