Moreover, mice lacking SETDB1 in Intestinal Stem Cells (ISCs) developed enteritis, which could not be rescued by IEC-caspase-8 knockdown or caspase inhibitor (Z-VAD-fmk), but by MLKL or RIPK3 deletion, indicating that targeting necroptosis specifically in ISCs may represent a new approach for IBD treatment [82]. The gene discussed is MLKL; the disease is inflammatory bowel disease.