The underexpressed GBM genes included the LINC00836 nonprotein-coding gene and 20 protein-coding genes (FERMT1, DLL3, P2RY12, CHST9, IFGN1, CSDC2, ETNPPL, VIPR2, MGAT4C, DLL1, TNR, GDF10, IRX2, SHANK2, ENHO, LUZP2, DPP10, CDHR1, AKR1C3 and SCG3) (Table 2). Here, SHANK2 is linked to glioblastoma.