Our results were the first ever to report that the overexpressed GPX8 gene and the underexpressed GBM CHST9, CSDC2, ENHO, FERMT1, IGFN1, LINC00836, MGAT4C and SHANK2 genes might play crucial roles in the tumorigenesis of different gliomas. The gene discussed is SHANK2; the disease is glioblastoma.