Identified molecular biomarkers of GBM include immune-related molecules [10], cytoskeletal proteins [12,13], nonprotein-coding RNAs [14] and signal-related molecules revealing signaling pathways that play crucial roles in GBM, i.e., EGFR [15,16], VEGF [17], sonic hedgehog (SHH) [18,19], Notch [20] and Wnt/β-catenin signaling [21,22]. Here, SHH is linked to glioblastoma.