Of the 21 underexpressed genes, 13 (AKR1C3, CDHR1, DLL1, DLL3, DPP10, ETNPPL, GDF10, IRX2, LUZP2, P2RY12, SCG3, TNR and VIPR2) are reportedly associated with gliomas (Table 4). Here, AKR1C3 is linked to central nervous system cancer.