Of the 21 underexpressed genes, 13 (AKR1C3, CDHR1, DLL1, DLL3, DPP10, ETNPPL, GDF10, IRX2, LUZP2, P2RY12, SCG3, TNR and VIPR2) are reportedly associated with gliomas (Table 4). Here, IRX2 is linked to central nervous system cancer.