PGK1 and amyotrophic lateral sclerosis: Thus, they demonstrated that Pgk1 secreted from muscle cells could promote neurite outgrowth of motor neurons, resulting in the alleviation of NMJ denervation and the progressive loss of motor ability in both ALS mice and ALS-like zebrafish animal models, suggesting that extracellular Pgk1 emits a cross-tissue communication signal between muscle and neuronal cells.