PGK1 and neoplasm: Lay et al. reported that Pgk1 secreted from human fibrosarcoma, breast, colon, and pancreatic tumor cells participates in the anti-angiogenic process through its disulphide reductase activity, which reduces the disulphide bonds in plasmin to release the tumor blood vessel inhibitor Angiostatin, which, in turn, inhibits tumor angiogenesis and growth in mice [54].