CRH and Alzheimer disease: Importantly, serum CRH level was found to be elevated in untreated AD (31.0 ± 19.5 pg/mL) as well as in psoriasis (22.5 ± 13.7 pg/mL) as compared to healthy individuals (9.7 ± 4.2 pg/mL), while CRH-1 receptor was downregulated in the lesional epidermis of the said patients (immunohistochemistry) [263].