Thus, although the effect of IL-13 on the MOR expression of the keratinocytes has not been investigated yet, based on the above findings [103], one might speculate that IL-13-mediated pathological inflammatory response may prevent activation-induced downregulation of MOR [99,128] in lesional keratinocytes of AD patients, maintaining pathologically prolonged MOR activity. This evidence concerns the gene IL13 and Alzheimer disease.