As mentioned above, in a DNFB-induced contact dermatitis model of male Swiss Webster mice, the KOR agonist and MOR and DOR partial agonist (i.e., technically a MOR- and DOR-blocker) Nalbuphine (10 mg/kg; s.c.; 20 min prior to DNFB) was found to attenuate pruritus. Here, OPRK1 is linked to contact dermatitis.