From this perspective, it seems to be important to emphasize that 24 h treatment with the highly AD-relevant [145,146] cytokine IL-13 (100 ng) upregulated MOR (the most important receptor of β-endorphin) in human monocyte-derived LCs that were activated by a 48 h treatment of the combination of 1 μg/mL LPS and poly-(I:C) (10 μg/50,000 cells) [147]. This evidence concerns the gene OPRM1 and Alzheimer disease.