In the research of Yang et al. [81], the circ_0000950 appeared directly involved in neuroinflammation since by sponging mir-103, it led to the expression increase of a proinflammatory gene, prostaglandin-endoperoxide synthase 2 (PTGS2) in two different in vitro AD models (Table 2). This evidence concerns the gene PTGS2 and Alzheimer disease.