In the same mouse model, circNF1-419 increased autophagy, reducing the expression of AD markers such as Tau, p-Tau, Aβ1-42, and APOE, and ameliorated senile dementia by binding Dinamin-1 and Adaptor protein 2 B1 (AP2B1), influencing multiple signaling pathways, especially at the synapse [83]. Here, MAPT is linked to Alzheimer disease.