The concept that circRNAs could also play a prominent role in FTD was raised for the first time by Cervera-Carles and colleagues’ study [63], where two circRNAs, circHOMER1 and circKCNN2, were significantly decreased in a group of FTLD-Tau and FTLD-TDP43 brain samples (Table 1) [63]. Here, MAPT is linked to frontotemporal dementia.