A2M belongs to the LRP1–A2M–annexin VI complex, which was suggested as a significantly enriched protein complex both in AD and MCI OM cells compared to controls based on the functional analysis of the DEGs using the CORUM (the comprehensive resource of mammalian protein complexes) database (CORUM:2710, for AD p = 0.012, for MCI p = 0.032). The gene discussed is LRP1; the disease is Alzheimer disease.