KRAS and cancer: GTP-bound KRAS transduces signals to downstream effectors and stimulates multiple signaling pathways [6,7], including the RAF family of kinases and phosphatidylinositol 3-kinase (PI3K), that in turn activate a cascade of events and influence a multitude of cellular processes, including cell proliferation, differentiation, survival, growth and apoptosis, all renowned hallmarks of cancer [8].