These results are also consistent with the findings that Tβ4 induced activation of the Akt pathway in medulloblastoma cells, contributing to an increase in the cellular resistance to chemotherapy with a non-elevated basal level of p53 but had the opposite effect on cells with increased p53 expression, which was caused, in particular, by oncogenic p53 mutations [206]. Here, TP53 is linked to medulloblastoma.