In addition to Ca2+ dysregulation, the overexpression of calpain-1 and calpain-2 is a common feature of preclinical models of cardiac remodeling and HF, including MI with transient and permanent LAD ligation, TAC, and chronic administration of isoproterenol and angiotensin II [14,38,41,89,90,91], and it has also been confirmed in myocardial samples from patients with HF [41,57,90,92,93]. Here, CAPN2 is linked to hydrops fetalis.