Providing further evidence of calpain contribution to myocardial remodeling, the inhibition of calpain by deletion of Capn4 prevented hypertrophy in a model of pulmonary hypertension [100], and calpastatin overexpression reduced myocardial hypertrophy and fibrosis in a mouse model of type 1 diabetes [101]. Here, CAST is linked to type 1 diabetes mellitus.