SNEA eosinophils significantly promoted the gene expression of Smad2, Smad3, Smad4, Smad5, Smad7, and Smad9 in ASMC, and Smad1, Smad2, Smad3, Smad4, and Smad7 in PF compared with control cells. This evidence concerns the gene SMAD5 and pemphigus foliaceus.