TGFB1 and asthma: The elevated levels of TGF-β and its receptors create the “vicious circle”: eosinophil-secreted TGF-β binds to its receptors on the surface of ASMC and PF, thus promoting the expression of TGF-β signaling pathway components, ECM proteins, MMPs, and TIMPs, further promoting inflammatory processes in asthma [2,46,53,65].