NAPEPLD and Insulin resistance: In particular, NAPE-PLD regulates fat metabolism and absorption, while its deletion leads to insulin resistance, glucose tolerance, altered lipid and gut microbiota composition (e.g., increased Alcaligenaceae, Bacteroidaceae, Clostridiaceae, Coriobacteriaceae, Erysipelotrichaceae, and Lactobacillaceae families) in an adipose tissue-specific Napepld-deleted mice (cKO mice) model [142].