In the same direction, another review suggests that the clinical presentation of malaria, including the development of severe cases, appears to depend on a balance between pro-inflammatory and regulatory molecular and cellular mechanisms, although the precise role of regulatory cytokines (IL-10, transforming growth factor beta (TGFß)) and cells (regulatory T lymphocytes, IL-10-producing T lymphocytes) has not been completely solved [16]. This evidence concerns the gene IL10 and malaria.