Lipopolysaccharide is a potent inducer of inflammation, as testified by increased levels of ROS, TLR4, inflammatory cytokines, including IL-10, IL-6, TNF-α, IL-1β, and activation of the NF-kB pathway in K562 CML cell lines [91]. Here, TNF is linked to chronic myelogenous leukemia, BCR-ABL1 positive.