Different molecular pathways have been related to metastatic dissemination in HNSCC, including the transforming growth factor β (TGF-β), the fibroblast growth factor receptor (FGFR), and the chemokine receptor 4 (CXCR4), among others [3,4,5,6,7]. This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.