MAGEA3 and cancer: In addition, TAAs can be cell-lineage-differentiation antigens (e.g., prostate-specific antigen (PSA) and prostatic-acid phosphatase (PAP), which are typically not expressed in adult tissues [15,16], and cancer/germline antigens (also known as cancer/testis) (e.g., melanoma-associated antigen 1 (MAGE-A1), melanoma-associated antigen 3 (MAGE-A3), New York esophageal squamous-cell carcinoma 1 (NY-ESO-1), and preferentially expressed antigen of melanoma (PRAME), which are typically only expressed in immune-privileged germline cells [17,18,19,20,21].