Therefore, further in vitro studies will be carried out in a PD cellular model (M17 cells overexpressing α-synuclein or BE(2)-M17 cells with depletion of lysosomal type 5 P-type ATPase (ATP13A2)) and further characterization, in particular autophagy flux experiments associated with GNL-based nanosystems will be assessed. Here, ATP13A2 is linked to Parkinson disease.