These results are in line with previous findings about TCAs: Ma et al. [39] report that the CHOP-dependent ER stress pathway is responsible for desipramine-induced apoptosis in C6 glioma cells, and it appears that this apoptotic effect occurs through the PERK-eIF2α and ATF6 signalling pathways [45]. The gene discussed is ATF6; the disease is glioma.