Generally, the ICV route is used for injecting chemical compounds and peptides, such as colchicine, okadaic acid, streptozotocin, scopolamine, Aβ1-42, and hyperphosphorylated tau (p-tau), directly into the cerebral lateral ventricles to induce AD in different experimental animal models [81,82,83]. Here, MAPT is linked to Alzheimer disease.