Furthermore, we tried to better understand the toxicological influences and to investigate the cellular inflammatory infiltrate, which surround the tumor areas through the investigation of histopathological traits and tumor markers (CEA, CA, TNF-alpha, and Interleukin-6 (IL-6)), which were measured in the blood samples of rats before and after treatment to evaluate the suppression effect on tumor cells by the modified hydrogels. The gene discussed is TNF; the disease is neoplasm.