Within the context of cystic fibrosis (CF), an inherited recessive autosomal disorder caused by mutations in the gene cystic fibrosis transmembrane conductance regulator (CFTR), several peptides have been proposed as therapy, such as the S18 peptide as an ENaC antagonist [3], the alpha-1 proteinase inhibitor (PI) to reduce neutrophil elastase burden [4] or antimicrobial peptides (e.g., Esculentin [5], M33 [6] and Colistin [7]). The gene discussed is CFTR; the disease is cystic fibrosis.