These data confirmed that functionalization of PEG62-b-PMLABe73-based NPs with peptides affected the formation of the protein corona and suggested that apolipoproteins ApoA-I and ApoE, two main components of HDL, may interact with CPB and GBVA10-9 and could regulate the cell uptake of functionalized NPs in hepatoma cells. This evidence concerns the gene CPB1 and hepatocellular carcinoma.