In contrast, evaluation of cell uptake of peptide-functionalized NPs demonstrated that both GBVA10-9 and its scramble-control peptides strongly enhanced internalization by hepatoma cells, suggesting that peptides physicochemical features and/or formation of a protein corona could be the main drivers of the NPs’ cell internalization, rather than the recognition of a membrane receptor mediated by a specific peptide sequence, unlike the CPB peptide, for which the amino acid sequence is determinant for the cell uptake. Here, CPB1 is linked to hepatocellular carcinoma.